4bl0: Difference between revisions

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~~'''Unreleased~~ structure~~'''~~

===Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105===

The ~~entry 4bl0~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/BUB3_YEAST BUB3_YEAST]] Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.<ref>PMID:15879521</ref> [[http://www.uniprot.org/uniprot/SP105_YEAST SP105_YEAST]] Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.<ref>PMID:19893618</ref> [[http://www.uniprot.org/uniprot/BUB1_YEAST BUB1_YEAST]] Involved in cell cycle checkpoint enforcement. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Catalyzes the phosphorylation of BUB3 and its autophosphorylation. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.<ref>PMID:12769845</ref>

~~Authors~~: ~~Primorac, I~~.~~, Weir, J~~.R.~~, Musacchio, A~~.

==About this Structure==

[[4bl0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL0 OCA].

~~Description~~: ~~Crystal structure of yeast Bub3~~-~~Bub1 bound to phosopho-Spc105~~

==Reference==

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Saccharomyces cerevisiae]]

[[Category: Musacchio, A.]]

[[Category: Primorac, I.]]

[[Category: Weir, J R.]]

[[Category: Aneuploidy]]

[[Category: Blinkin]]

[[Category: Bubr1]]

[[Category: Casc5]]

[[Category: Cell cycle]]

[[Category: Cell division]]

[[Category: Gle2]]

[[Category: Gleb]]

[[Category: Kinetochore]]

[[Category: Knl1]]

[[Category: Mad1]]

[[Category: Mad2]]

[[Category: Mad3]]

[[Category: Mitosis]]

[[Category: Rae1]]

[[Category: Spc7]]

[[Category: Spindle assembly checkpoint]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bl0|  PDB=4bl0  |  SCENE=  }}
+===Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105===
-The entry 4bl0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BUB3_YEAST BUB3_YEAST]] Required for cell cycle arrest in response to loss of microtubule function. Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.<ref>PMID:15879521</ref>  [[http://www.uniprot.org/uniprot/SP105_YEAST SP105_YEAST]] Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.<ref>PMID:19893618</ref>  [[http://www.uniprot.org/uniprot/BUB1_YEAST BUB1_YEAST]] Involved in cell cycle checkpoint enforcement. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Catalyzes the phosphorylation of BUB3 and its autophosphorylation. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.<ref>PMID:12769845</ref>
-Authors: Primorac, I., Weir, J.R., Musacchio, A.
+==About this Structure==
+[[4bl0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL0 OCA].
-Description: Crystal structure of yeast Bub3-Bub1 bound to phosopho-Spc105
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Musacchio, A.]]
+[[Category: Primorac, I.]]
+[[Category: Weir, J R.]]
+[[Category: Aneuploidy]]
+[[Category: Blinkin]]
+[[Category: Bubr1]]
+[[Category: Casc5]]
+[[Category: Cell cycle]]
+[[Category: Cell division]]
+[[Category: Gle2]]
+[[Category: Gleb]]
+[[Category: Kinetochore]]
+[[Category: Knl1]]
+[[Category: Mad1]]
+[[Category: Mad2]]
+[[Category: Mad3]]
+[[Category: Mitosis]]
+[[Category: Rae1]]
+[[Category: Spc7]]
+[[Category: Spindle assembly checkpoint]]