4l7j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)===

~~The entry 4l7j~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Huestis, M~~.P.~~, Liu, W~~.~~, Volgraf, M., Purkey, H.E., Wang, W., Yu, C., Wu, P., Smith, D., Vigers, G., Dutcher, D., Geck Do, M.K~~.~~, Hunt, K~~.W.~~, Siu, M~~.

==About this Structure==

[[4l7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA].

~~Description~~: ~~Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of~~ 2-~~hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

[[Category: Do, M K.Geck.]]

[[Category: Dutcher, D.]]

[[Category: Huestis, M P.]]

[[Category: Hunt, K W.]]

[[Category: Liu, W.]]

[[Category: Purkey, H E.]]

[[Category: Siu, M.]]

[[Category: Smith, D.]]

[[Category: Vigers, G.]]

[[Category: Volgraf, M.]]

[[Category: Wang, W.]]

[[Category: Wu, P.]]

[[Category: Yu, C.]]

[[Category: Aspartic protease]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4l7j|  PDB=4l7j  |  SCENE=  }}
+===Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)===
-The entry 4l7j is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Huestis, M.P., Liu, W., Volgraf, M., Purkey, H.E., Wang, W., Yu, C., Wu, P., Smith, D., Vigers, G., Dutcher, D., Geck Do, M.K., Hunt, K.W., Siu, M.
+==About this Structure==
+[[4l7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7J OCA].
-Description: Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Do, M K.Geck.]]
+[[Category: Dutcher, D.]]
+[[Category: Huestis, M P.]]
+[[Category: Hunt, K W.]]
+[[Category: Liu, W.]]
+[[Category: Purkey, H E.]]
+[[Category: Siu, M.]]
+[[Category: Smith, D.]]
+[[Category: Vigers, G.]]
+[[Category: Volgraf, M.]]
+[[Category: Wang, W.]]
+[[Category: Wu, P.]]
+[[Category: Yu, C.]]
+[[Category: Aspartic protease]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]