4b8e: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4b8e| PDB=4b8e | SCENE= }} | {{STRUCTURE_4b8e| PDB=4b8e | SCENE= }} | ||
===PRY-SPRY domain of Trim25=== | ===PRY-SPRY domain of Trim25=== | ||
{{ABSTRACT_PUBMED_24015671}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4b8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA]. | [[4b8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024015671</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Babon, J J.]] | [[Category: Babon, J J.]] | ||
Revision as of 06:49, 29 September 2013
PRY-SPRY domain of Trim25
Template:ABSTRACT PUBMED 24015671
Function
[TRI25_MOUSE] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
About this Structure
4b8e is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- D'Cruz AA, Kershaw NJ, Chiang JJ, Wang MK, Nicola NA, Babon JJ, Gack MU, Nicholson SE. Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling. Biochem J. 2013 Sep 10. PMID:24015671 doi:10.1042/BJ20121425
