1ht1: Difference between revisions
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{{STRUCTURE_1ht1| PDB=1ht1 | SCENE= }} | {{STRUCTURE_1ht1| PDB=1ht1 | SCENE= }} | ||
===Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU=== | ===Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU=== | ||
{{ABSTRACT_PUBMED_11709174}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref> [[http://www.uniprot.org/uniprot/HSLU_ECOLI HSLU_ECOLI]] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011709174</ref><references group="xtra"/> | <ref group="xtra">PMID:011709174</ref><references group="xtra"/><references/> | ||
[[Category: Chung, C H.]] | [[Category: Chung, C H.]] | ||
[[Category: Eom, S H.]] | [[Category: Eom, S H.]] | ||
