4btm: Difference between revisions
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{{STRUCTURE_4btm| PDB=4btm | SCENE= }} | |||
===TTBK1 in complex with inhibitor=== | |||
{{ABSTRACT_PUBMED_24039150}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TTBK1_HUMAN TTBK1_HUMAN]] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.<ref>PMID:16923168</ref> | |||
==About this Structure== | |||
[[4btm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024039150</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Dekker, N.]] | |||
[[Category: Hillertz, P.]] | |||
[[Category: Schweikart, F.]] | |||
[[Category: Wan, P.]] | |||
[[Category: Wissler, L.]] | |||
[[Category: Xue, Y.]] | |||
[[Category: Zhao, Y.]] | |||
[[Category: Ligand complex]] | |||
[[Category: Structure-kinetics relationship]] | |||
[[Category: Transferase]] | |||
Revision as of 08:11, 29 September 2013
TTBK1 in complex with inhibitor
Template:ABSTRACT PUBMED 24039150
Function
[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.[1]
About this Structure
4btm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Xue Y, Wan PT, Hillertz P, Schweikart F, Zhao Y, Wissler L, Dekker N. X-ray Structural Analysis of Tau-Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors. ChemMedChem. 2013 Sep 13. doi: 10.1002/cmdc.201300274. PMID:24039150 doi:10.1002/cmdc.201300274
