3zg2: Difference between revisions
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{{STRUCTURE_3zg2| PDB=3zg2 | SCENE= }} | |||
===Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512] | |||
==About this Structure== | |||
[[3zg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZG2 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Sterol 14-demethylase]] | |||
[[Category: Trypanosoma cruzi]] | |||
[[Category: Chatelain, E.]] | |||
[[Category: Hargrove, T Y.]] | |||
[[Category: Keenan, M.]] | |||
[[Category: Lepesheva, G I.]] | |||
[[Category: Wawrzak, Z.]] | |||
[[Category: Cytochrome p450 fold]] | |||
[[Category: Endoplasmic reticulum membrane]] | |||
[[Category: Eukaryotic membrane]] | |||
[[Category: Inhibitor]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Sterol biosynthesis]] | |||
Revision as of 08:15, 29 September 2013
Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)
Function
[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]
About this Structure
3zg2 is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
- ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200
