4c0a: Difference between revisions
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{{STRUCTURE_4c0a| PDB=4c0a | SCENE= }} | |||
===Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/ARF1_BOVIN ARF1_BOVIN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. | |||
==About this Structure== | |||
[[4c0a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0A OCA]. | |||
[[Category: Bos taurus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Aizel, K.]] | |||
[[Category: Biou, V.]] | |||
[[Category: Campanacci, V.]] | |||
[[Category: Cherfils, J.]] | |||
[[Category: Duarte, L.]] | |||
[[Category: Navaza, J.]] | |||
[[Category: Zeghouf, M.]] | |||
[[Category: Endocytosis]] | |||
[[Category: Protein transport]] | |||
Revision as of 08:16, 29 September 2013
Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain
Function
[ARF1_BOVIN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
About this Structure
4c0a is a 8 chain structure with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.
