4gdx: Difference between revisions
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{{STRUCTURE_4gdx| PDB=4gdx | SCENE= }} | |||
===Crystal Structure of Human Gamma-Glutamyl Transpeptidase--Glutamate complex=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref> | |||
==About this Structure== | |||
[[4gdx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GDX OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Cahill, K.]] | |||
[[Category: Chen, Y.]] | |||
[[Category: Hanigan, M H.]] | |||
[[Category: Heroux, A.]] | |||
[[Category: Mooers, B H.M.]] | |||
[[Category: West, M B.]] | |||
[[Category: Wickham, S.]] | |||
[[Category: Cell surface]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Hydrolase]] | |||
[[Category: N-glycosylation]] | |||
[[Category: Ntn-hydrolase family]] | |||
[[Category: Product-enzyme complex]] | |||
