4h8i: Difference between revisions
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{{STRUCTURE_4h8i| PDB=4h8i | SCENE= }} | |||
===Structure of GluK2-LBD in complex with GluAzo=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref> | |||
==About this Structure== | |||
[[4h8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8I OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Reiter, A.]] | |||
[[Category: Schiefner, A.]] | |||
[[Category: Skerra, A.]] | |||
[[Category: Trauner, D.]] | |||
[[Category: Gluazo]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Ion channel]] | |||
[[Category: Ion transport]] | |||
[[Category: Ionotropic glutamate receptor]] | |||
[[Category: Kainate receptor]] | |||
[[Category: Ligand-binding domain]] | |||
[[Category: Membrane protein]] | |||
[[Category: Me]] | |||
[[Category: Pcl]] | |||
[[Category: Photochromic ligand]] | |||
[[Category: Postsynaptic cell membrane]] | |||
[[Category: Presynaptic cell membrane]] | |||
[[Category: Signaling protein]] | |||
[[Category: Synapse]] | |||
[[Category: Transmembrane protein]] | |||