4men: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4men|  PDB=4men  |  SCENE=  }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand===


The entry 4men is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 


Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Fedorov, O., Vidler, L.R., Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Hoelder, S., Knapp, S., Structural Genomics Consortium (SGC)
==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand
==About this Structure==
[[4men]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MEN OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Brown, N.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A M.]]
[[Category: Fedorov, O.]]
[[Category: Felletar, I.]]
[[Category: Filippakopoulos, P.]]
[[Category: Hoelder, S.]]
[[Category: Knapp, S.]]
[[Category: Martin, S.]]
[[Category: Picaud, S.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Vidler, L R.]]
[[Category: Weigelt, J.]]
[[Category: Brd]]
[[Category: Brd4]]
[[Category: Cap]]
[[Category: Hunk1]]
[[Category: Mcap]]
[[Category: Mitotic chromosome associated protein]]
[[Category: Sgc]]
[[Category: Small molecule inhibitor]]
[[Category: Structural genomics consortium]]
[[Category: Transcription-transcription inhibitor complex]]
Retrieved from "https://proteopedia.org/4men"