HMG-CoA Reductase: Difference between revisions
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<StructureSection load='1dq8' size='450' side='right' scene='HMG-CoA_Reductase/1dq8_starting_scene/1' caption='Crystal Structure of HMG-CoA, [[1dq8]])'>[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. See also [[Ephrin Type-A Receptor]] and [[Neurodevelopmental Disorders]]. | <StructureSection load='1dq8' size='450' side='right' scene='HMG-CoA_Reductase/1dq8_starting_scene/1' caption='Crystal Structure of HMG-CoA, (PDB code [[1dq8]])'>[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. See also [[Ephrin Type-A Receptor]] and [[Neurodevelopmental Disorders]]. | ||
[[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] | [[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] | ||
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=== | ===HMGCR=== | ||
[[1r7i]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/> | [[1r7i]], [[4i64]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/> | ||
[[3qae]], [[3qau]] - PmHMGCR (mutant) - ''Streptococcus pneumoniae'' <br/> | [[3qae]], [[3qau]] - PmHMGCR (mutant) - ''Streptococcus pneumoniae'' <br/> | ||
=== | ===HMGCR+statins=== | ||
[[3cct]], [[3ccw]], [[3ccz]], [[3cd0]], [[3cd5]], [[3cd7]], [[3cda]], [[3cdb]], [[2r4f]], [[3bgl]], [[2q1l]], [[2q6b]], [[2q6c]], [[1hw8]], [[1hw9]], [[1hwi]], [[1hwj]], [[1hwk]], [[1hwl]] – HMG-CoA Reductase Catalytic Domain + Statins <br /> | [[3cct]], [[3ccw]], [[3ccz]], [[3cd0]], [[3cd5]], [[3cd7]], [[3cda]], [[3cdb]], [[2r4f]], [[3bgl]], [[2q1l]], [[2q6b]], [[2q6c]], [[1hw8]], [[1hw9]], [[1hwi]], [[1hwj]], [[1hwk]], [[1hwl]] – HMG-CoA Reductase Catalytic Domain + Statins <br /> | ||
[[1t02]] - PmHMGCR catalytic domain + statin derivatives <br /> | [[1t02]] - PmHMGCR catalytic domain + statin derivatives <br /> | ||
=== | ===HMGCR+cofactors=== | ||
[[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br /> | [[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br /> | ||
[[1qax]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br /> | [[1qax]], [[4i4b]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br /> | ||
[[4i56]] - PmHMGCR catalytic domain + dithio-HMG+CoA<br /> | |||
[[4i6a]] - PmHMGCR catalytic domain + HMG+CoA<br /> | |||
[[4i6w]] - PmHMGCR catalytic domain + thiomevalonate<br /> | |||
[[4i6y]] - PmHMGCR catalytic domain + mevalonate<br /> | |||
[[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br /> | [[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br /> | ||
[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br /> | [[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br /> | ||
