4gv5: Difference between revisions
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==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/ | [[http://www.uniprot.org/uniprot/MYXC_CRODU MYXC_CRODU]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.<ref>PMID:1176086</ref> <ref>PMID:9839677</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4gv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4gv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV5 OCA]. | ||
[[Category: Crotalus durissus | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Crotalus durissus terrificus]] | |||
[[Category: Arni, R K.]] | [[Category: Arni, R K.]] | ||
[[Category: Betzel, C.]] | [[Category: Betzel, C.]] | ||
Revision as of 05:58, 2 October 2013
X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus
Function
[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.[1] [2]
About this Structure
4gv5 is a 3 chain structure with sequence from Crotalus durissus terrificus. Full crystallographic information is available from OCA.
Reference
- ↑ Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
- ↑ Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677
