4kbm: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4kbm|  PDB=4kbm  |  SCENE=  }}
===Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex===


The entry 4kbm is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/RPOB_MYCTU RPOB_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [[http://www.uniprot.org/uniprot/CARD_MYCTU CARD_MYCTU]] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.<ref>PMID:19596241</ref> <ref>PMID:22904282</ref>  


Authors: Gulten, G., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
==About this Structure==
[[4kbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBM OCA].  


Description: Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex
==Reference==
<references group="xtra"/><references/>
[[Category: DNA-directed RNA polymerase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Gulten, G.]]
[[Category: Sacchettini, J C.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Card]]
[[Category: Dna]]
[[Category: Dna-dependent rna polymerase]]
[[Category: Protein-protein complex]]
[[Category: Sigma factor]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Transcription regulator]]
[[Category: Transferase-transcription complex]]
[[Category: Tudor]]

Revision as of 07:35, 2 October 2013

Template:STRUCTURE 4kbm

Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex

Function

[RPOB_MYCTU] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [CARD_MYCTU] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.[1] [2]

About this Structure

4kbm is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  1. ↑ Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041. PMID:19596241 doi:10.1016/j.cell.2009.04.041
  2. ↑ Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol. 2012 Oct;194(20):5621-31. Epub 2012 Aug 17. PMID:22904282 doi:10.1128/JB.00879-12

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