4i0d: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4i0d|  PDB=4i0d  |  SCENE=  }}
+===Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors===
+{{ABSTRACT_PUBMED_23570791}}
-The entry 4i0d is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Yao, N., Brecht,E.
+==About this Structure==
+[[4i0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0D OCA].
-Description: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
+==Reference==
+<ref group="xtra">PMID:023570791</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Brecht,E.]]
+[[Category: Yao, N.]]
+[[Category: Aspartic protease]]
+[[Category: Bace]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Hydrolysis]]

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