4c0g: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of the NOT-box domain of human CNOT3===

~~The entry 4c0g is ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Precursor T-cell acute lymphoblastic leukemia.

~~Authors~~: ~~Boland, A~~., ~~Chen~~, Y.~~, Raisch, T~~.~~, Jonas, S~~.~~, Izaurralde, E~~.~~, Weichenrieder, O~~.

==Function==

[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.<ref>PMID:14707134</ref> <ref>PMID:22342980</ref> <ref>PMID:22367759</ref>

~~Description~~: ~~Structure of the NOT~~-~~box domain of human CNOT3~~

==About this Structure==

[[4c0g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0G OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Boland, A.]]

[[Category: Chen, Y.]]

[[Category: Izaurralde, E.]]

[[Category: Jonas, S.]]

[[Category: Raisch, T.]]

[[Category: Weichenrieder, O.]]

[[Category: Ccr4-not]]

[[Category: Deadenylation]]

[[Category: Gene regulation]]

[[Category: Hydrolase]]

[[Category: Mrna decay]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c0g|  PDB=4c0g  |  SCENE=  }}
+===Structure of the NOT-box domain of human CNOT3===
-The entry 4c0g is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Precursor T-cell acute lymphoblastic leukemia.
-Authors: Boland, A., Chen, Y., Raisch, T., Jonas, S., Izaurralde, E., Weichenrieder, O.
+==Function==
+[[http://www.uniprot.org/uniprot/CNOT3_HUMAN CNOT3_HUMAN]] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.<ref>PMID:14707134</ref> <ref>PMID:22342980</ref> <ref>PMID:22367759</ref>
-Description: Structure of the NOT-box domain of human CNOT3
+==About this Structure==
+[[4c0g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0G OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Boland, A.]]
+[[Category: Chen, Y.]]
+[[Category: Izaurralde, E.]]
+[[Category: Jonas, S.]]
+[[Category: Raisch, T.]]
+[[Category: Weichenrieder, O.]]
+[[Category: Ccr4-not]]
+[[Category: Deadenylation]]
+[[Category: Gene regulation]]
+[[Category: Hydrolase]]
+[[Category: Mrna decay]]
+[[Category: Transcription]]