4m66: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the mouse RIP3 kinase domain===

~~The entry 4m66 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>

~~Authors~~: ~~Xie, T~~.~~, Peng, W~~.~~, Yan, C~~.~~, Wu, J~~.~~, Shi, Y~~.

==About this Structure==

[[4m66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M66 OCA].

~~Description~~: ~~Crystal structure of the mouse RIP3~~ kinase ~~domain~~

==Reference==

[[Category: Mus musculus]]

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Peng, W.]]

[[Category: Shi, Y.]]

[[Category: Wu, J.]]

[[Category: Xie, T.]]

[[Category: Yan, C.]]

[[Category: Kinase]]

[[Category: Protein phosphorylation]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m66|  PDB=4m66  |  SCENE=  }}
+===Crystal structure of the mouse RIP3 kinase domain===
-The entry 4m66 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
-Authors: Xie, T., Peng, W., Yan, C., Wu, J., Shi, Y.
+==About this Structure==
+[[4m66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M66 OCA].
-Description: Crystal structure of the mouse RIP3 kinase domain
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Peng, W.]]
+[[Category: Shi, Y.]]
+[[Category: Wu, J.]]
+[[Category: Xie, T.]]
+[[Category: Yan, C.]]
+[[Category: Kinase]]
+[[Category: Protein phosphorylation]]
+[[Category: Transferase]]