4m69: Difference between revisions
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{{STRUCTURE_4m69| PDB=4m69 | SCENE= }} | |||
===Crystal structure of the mouse RIP3-MLKL complex=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref> [[http://www.uniprot.org/uniprot/MLKL_MOUSE MLKL_MOUSE]] Required for the execution of programmed necrosis (By similarity). | |||
==About this Structure== | |||
[[4m69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M69 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Peng, W.]] | |||
[[Category: Shi, Y.]] | |||
[[Category: Wu, J.]] | |||
[[Category: Xie, T.]] | |||
[[Category: Yan, C.]] | |||
[[Category: Kinase]] | |||
[[Category: Phosphorylation]] | |||
[[Category: Transferase-signaling protein complex]] | |||
Revision as of 08:10, 16 October 2013
Crystal structure of the mouse RIP3-MLKL complex
Function
[RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).[1] [MLKL_MOUSE] Required for the execution of programmed necrosis (By similarity).
About this Structure
4m69 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10. PMID:19590578 doi:https://dx.doi.org/10.1038/embor.2009.109
