4kp7: Difference between revisions
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===Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin=== | ===Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin=== | ||
{{ABSTRACT_PUBMED_24032981}} | {{ABSTRACT_PUBMED_24032981}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/DXR_PLAFX DXR_PLAFX]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).<ref>PMID:10477522</ref> | |||
==About this Structure== | ==About this Structure== | ||
Revision as of 08:25, 30 October 2013
Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin
Template:ABSTRACT PUBMED 24032981
Function
[DXR_PLAFX] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[1]
About this Structure
4kp7 is a 2 chain structure with sequence from Plasmodium falciparum hb3. Full crystallographic information is available from OCA.
Reference
- Kunfermann A, Lienau C, Illarionov B, Held J, Grawert T, Behrendt CT, Werner P, Hahn S, Eisenreich W, Riederer U, Mordmuller B, Bacher A, Fischer M, Groll M, Kurz T. IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation and structural biology of fosmidomycin thia-isosters. J Med Chem. 2013 Sep 13. PMID:24032981 doi:10.1021/jm4012559
