2jix: Difference between revisions
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{{STRUCTURE_2jix| PDB=2jix | SCENE= }} | {{STRUCTURE_2jix| PDB=2jix | SCENE= }} | ||
=== | ===Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor=== | ||
{{ABSTRACT_PUBMED_17620453}} | {{ABSTRACT_PUBMED_17620453}} | ||
==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN]] Defects in EPOR are the cause of familial erythrocytosis type 1 (ECYT1) [MIM:[http://omim.org/entry/133100 133100]]. ECYT1 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia.<ref>PMID:8506290</ref><ref>PMID:8174675</ref><ref>PMID:8608241</ref> | [[http://www.uniprot.org/uniprot/EPOR_HUMAN EPOR_HUMAN]] Defects in EPOR are the cause of familial erythrocytosis type 1 (ECYT1) [MIM:[http://omim.org/entry/133100 133100]]. ECYT1 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia.<ref>PMID:8506290</ref> <ref>PMID:8174675</ref> <ref>PMID:8608241</ref> | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[2jix]] is a 9 chain structure with sequence from | [[2jix]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIX OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017620453</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:017620453</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: DeVries, P.]] | ||
[[Category: Egan, D A.]] | [[Category: Egan, D A.]] | ||
[[Category: Harlan, J E.]] | [[Category: Harlan, J E.]] | ||
