4m4d: Difference between revisions
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{{STRUCTURE_4m4d| PDB=4m4d | SCENE= }} | |||
===Crystal structure of lipopolysaccharide binding protein=== | |||
{{ABSTRACT_PUBMED_24120359}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LBP_MOUSE LBP_MOUSE]] Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). | |||
==About this Structure== | |||
[[4m4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4D OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024120359</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: An, H J.]] | |||
[[Category: Eckert, J K.]] | |||
[[Category: Giamarellos-Bourboulis, E.]] | |||
[[Category: Gurtler, K.]] | |||
[[Category: Hamann, L.]] | |||
[[Category: Kabesch, M.]] | |||
[[Category: Kim, J I.]] | |||
[[Category: Kim, Y J.]] | |||
[[Category: Kubarenko, A V.]] | |||
[[Category: Kumpf, O.]] | |||
[[Category: Lee, J O.]] | |||
[[Category: Lundvall, L.]] | |||
[[Category: Oh, D Y.]] | |||
[[Category: Pickkers, P.]] | |||
[[Category: Ploeg, A H.]] | |||
[[Category: Schumann, R R.]] | |||
[[Category: Weber, A N.]] | |||
[[Category: Beta barrel]] | |||
[[Category: Blood]] | |||
[[Category: Immune response]] | |||
[[Category: Lipid binding protein]] | |||
[[Category: Lipopolysaccharide]] | |||
Revision as of 09:44, 30 October 2013
Crystal structure of lipopolysaccharide binding protein
Template:ABSTRACT PUBMED 24120359
Function
[LBP_MOUSE] Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity).
About this Structure
4m4d is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Eckert JK, Kim YJ, Kim JI, Gurtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity. 2013 Oct 17;39(4):647-60. doi: 10.1016/j.immuni.2013.09.005. Epub 2013 , Oct 10. PMID:24120359 doi:https://dx.doi.org/10.1016/j.immuni.2013.09.005
