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==='''Introduction'''===
==='''Introduction'''===
Peptidoglycan transpeptidase (TP) also known as penicillin-binding proteins (PBP), are essential for bacterial cell wall synthesis and catalyze the cross-linking of peptidoglycan polymers during bacterial wall synthesis.[http://en.wikipedia.org/wiki/Beta-lactam_antibiotic Beta-lactam antibiotic], which includes the penicillins,cephalosporins,carbapenems, and the monobactam aztreonam, bind and irreversibly inhibit the active site of TP. The overuse and misuse of b-lactam antibiotics has led to strains of ''Staphylococcus aureus (S.aureus)'' that are resistant to all currently available b-lactams and are often susceptible to so-called "last resort antibiotics", such as vancomycin.
Peptidoglycan transpeptidase (TP) also known as penicillin-binding proteins (PBP), are essential for bacterial cell wall synthesis and catalyze the cross-linking of peptidoglycan polymers during bacterial wall synthesis.[http://en.wikipedia.org/wiki/Beta-lactam_antibiotic Beta-lactam antibiotic], which includes the penicillins,cephalosporins,carbapenems, and the monobactam aztreonam (figure 1); bind and irreversibly inhibit the active site of TP. The overuse and misuse of b-lactam antibiotics has led to strains of ''Staphylococcus aureus (S.aureus)'' that are resistant to all currently available b-lactams and are often susceptible to so-called "last resort antibiotics", such as vancomycin.




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