Single stranded binding protein: Difference between revisions
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SSB can form complexes with many other proteins. This trait can keep enzymes needed for damage repair, transcription, etc. near the ssDNA and it is thought that SSB can even help to stimulate these enzymes to carry out their jobs. When DNA binds SSB, most of the molecule loses flexibility. But the COOH terminal domain remain flexible, even after DNA binding. It is believed that the COOH terminus has something to do with protein binding <ref>PMID: 2087220</ref>. | SSB can form complexes with many other proteins. This trait can keep enzymes needed for damage repair, transcription, etc. near the ssDNA and it is thought that SSB can even help to stimulate these enzymes to carry out their jobs. When DNA binds SSB, most of the molecule loses flexibility. But the COOH terminal domain remain flexible, even after DNA binding. It is believed that the COOH terminus has something to do with protein binding <ref>PMID: 2087220</ref>. | ||
SSB will interact with the protein RecA to enable recombination, because RecA will recognize SSB and replace it on the strand. | |||
In DNA repair, SSB will bind to the damaged strand to protect it. And eventually it will attract repair enzymes which will replace SSB and begin repair mechanisms. | |||
SSB has also been thought to bind with exonuclease I, DNA polymerase II, | SSB has also been thought to bind with exonuclease I, DNA polymerase II, | ||
