2vpg: Difference between revisions
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{{STRUCTURE_2vpg| PDB=2vpg | SCENE= }} | {{STRUCTURE_2vpg| PDB=2vpg | SCENE= }} | ||
=== | ===Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex=== | ||
{{ABSTRACT_PUBMED_18498752}} | {{ABSTRACT_PUBMED_18498752}} | ||
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==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref> | [[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref> | ||
==About this Structure== | ==About this Structure== | ||
Revision as of 06:21, 6 November 2013
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
Template:ABSTRACT PUBMED 18498752
Disease
[BCL9_HUMAN] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
Function
[BCL9_HUMAN] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).[1]
About this Structure
2vpg is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fiedler M, Sanchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Muller J, Evans P, Bienz M. Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol Cell. 2008 May 23;30(4):507-18. PMID:18498752 doi:10.1016/j.molcel.2008.03.011
