4cbf: Difference between revisions
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{{STRUCTURE_4cbf| PDB=4cbf | SCENE= }} | |||
===Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus=== | |||
{{ABSTRACT_PUBMED_24155405}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/E0WXI2_9FLAV E0WXI2_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] | |||
==About this Structure== | |||
[[4cbf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBF OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024155405</ref><references group="xtra"/><references/> | |||
[[Category: Dengue virus 2]] | |||
[[Category: Dengue virus 4]] | |||
[[Category: Chew, P L.]] | |||
[[Category: Kostyuchenko, V A.]] | |||
[[Category: Lok, S M.]] | |||
[[Category: Ng, T S.]] | |||
[[Category: Flavivirus]] | |||
[[Category: Virus]] | |||
Revision as of 07:39, 6 November 2013
Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus
Template:ABSTRACT PUBMED 24155405
Function
[E0WXI2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
About this Structure
4cbf is a 6 chain structure with sequence from Dengue virus 2 and Dengue virus 4. Full crystallographic information is available from OCA.
Reference
- Kostyuchenko VA, Chew PL, Ng TS, Lok SM. Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus. J Virol. 2013 Oct 23. PMID:24155405 doi:https://dx.doi.org/10.1128/JVI.02641-13
