4lv7: Difference between revisions
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{{STRUCTURE_4lv7| PDB=4lv7 | SCENE= }} | |||
===Crystal structure of inositol 1,3,4,5,6-pentakisphosphate 2-kinase E82C/S142C=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref> | |||
==About this Structure== | |||
[[4lv7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV7 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Inositol-pentakisphosphate 2-kinase]] | |||
[[Category: Gosein, V.]] | |||
[[Category: Miller, G J.]] | |||
[[Category: Atipk1]] | |||
[[Category: Inositol phosphorylation]] | |||
[[Category: Ins5p 2-k]] | |||
[[Category: Ip5 2-k]] | |||
[[Category: Ipk]] | |||
[[Category: Transferase]] | |||
Revision as of 07:51, 6 November 2013
Crystal structure of inositol 1,3,4,5,6-pentakisphosphate 2-kinase E82C/S142C
Function
[IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.[1] [2]
About this Structure
4lv7 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
- ↑ Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. Epub 2005 Aug 17. PMID:16107538 doi:10.1073/pnas.0504172102
- ↑ Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. PMID:16223361 doi:BJ20051331
