4m4z: Difference between revisions
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{{STRUCTURE_4m4z| PDB=4m4z | SCENE= }} | |||
===SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)=== | |||
{{ABSTRACT_PUBMED_24018043}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. | |||
==About this Structure== | |||
[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024018043</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: McGlade, C J.]] | |||
[[Category: Wybenga-Groot, L E.]] | |||
[[Category: Adaptor]] | |||
[[Category: Sh3 and sh2 domain]] | |||
[[Category: Signaling protein]] | |||
Revision as of 07:52, 6 November 2013
SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)
Template:ABSTRACT PUBMED 24018043
Function
[SLAP2_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
About this Structure
4m4z is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wybenga-Groot LE, McGlade CJ. Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation. Cell Signal. 2013 Dec;25(12):2702-8. doi: 10.1016/j.cellsig.2013.08.040. Epub, 2013 Sep 7. PMID:24018043 doi:https://dx.doi.org/10.1016/j.cellsig.2013.08.040
