Sandbox vdr: Difference between revisions
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== Vitamin D Receptor == | == Vitamin D Receptor == | ||
'''Vitamin D receptor'''(<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. VDR contains a | '''Vitamin D receptor''' (<scene name='56/562378/Vit_d_receptor_3m7r/3'>VDR</scene>) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. VDR contains a | ||
<scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene>. | <scene name='56/562378/Lbd/1'>ligand binding domain (LBD)</scene> and <scene name='56/562378/Dbd/2'>DNA-binding domain (DBD)</scene>. | ||
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<scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | ||
<scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | <scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | ||
==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ||
