Sandbox vdr: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Isita Amin (talk | contribs) No edit summary |
Isita Amin (talk | contribs) |
||
| Line 18: | Line 18: | ||
==Mutation== | ==Mutation== | ||
Serine/ threonine kinase plays a crucial role in signal transduction pathways drawn out by variety of growth factors, hormones, and neurotransmitters. When <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>serine</scene> is mutated it is replaced | Serine/ threonine kinase plays a crucial role in signal transduction pathways drawn out by variety of growth factors, hormones, and neurotransmitters. When <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>serine</scene> is mutated it is replaced with a <scene name='56/562378/Vit_d_receptor_3m7r_serine/8'>glycine</scene> which results in an inhibition of transcriptional activation. When transcription is inhibited it results in p53 accumulation, which activates and promotes p53 translocation into mitochondria leading to apoptosis. Transcription inhibition is useful in cancer patients and so can be used as treatment option. | ||
<scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | ||
<scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | <scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | ||
==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ||
