Sandbox vdr: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Isita Amin (talk | contribs) |
Isita Amin (talk | contribs) No edit summary |
||
| Line 23: | Line 23: | ||
<scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>Serine</scene> is replaced with | ||
<scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | <scene name='56/562378/Vit_d_receptor_3m7r_serine/9'>aspartic acid</scene> when mutated creating a negative charge. The negative charge at the residue inhibits DNA binding which cause a down – regulation of VDR activity. VDR needs DNA binding in order for it to be activated which is only possible with a serine residue. | ||
==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ==Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)== | ||
