3g60: Difference between revisions
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{{STRUCTURE_3g60| PDB=3g60 | SCENE= }} | {{STRUCTURE_3g60| PDB=3g60 | SCENE= }} | ||
===Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding=== | ===Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding=== | ||
{{ABSTRACT_PUBMED_19325113}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3g60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3g60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. The March 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''P-glycoprotein'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_3 10.2210/rcsb_pdb/mom_2010_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G60 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019325113</ref><references group="xtra"/> | <ref group="xtra">PMID:019325113</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: P-glycoprotein]] | [[Category: P-glycoprotein]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
Revision as of 06:28, 13 November 2013
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Template:ABSTRACT PUBMED 19325113
Function
[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]
About this Structure
3g60 is a 2 chain structure with sequence from Lk3 transgenic mice. The March 2010 RCSB PDB Molecule of the Month feature on P-glycoprotein by David Goodsell is 10.2210/rcsb_pdb/mom_2010_3. Full crystallographic information is available from OCA.
Reference
- Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
- ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
