4i2f: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4i2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4i2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I2F OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023856622</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023856622</ref><references group="xtra"/><references/> | ||
[[Category: DNA nucleotidylexotransferase]] | [[Category: DNA nucleotidylexotransferase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Delarue, M.]] | [[Category: Delarue, M.]] | ||
[[Category: Gouge, J.]] | [[Category: Gouge, J.]] | ||
[[Category: Terminal transferase]] | [[Category: Terminal transferase]] | ||
[[Category: Transferase-dna complex]] | [[Category: Transferase-dna complex]] | ||
Revision as of 06:42, 13 November 2013
Binary complex of mouse TdT with ssDNA
Template:ABSTRACT PUBMED 23856622
Function
[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
About this Structure
4i2f is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
Reference
- Gouge J, Rosario S, Romain F, Beguin P, Delarue M. Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J Mol Biol. 2013 Jul 13. pii: S0022-2836(13)00441-5. doi:, 10.1016/j.jmb.2013.07.009. PMID:23856622 doi:10.1016/j.jmb.2013.07.009
