4c11: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4c11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus | [[4c11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C11 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024025331</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024025331</ref><references group="xtra"/><references/> | ||
[[Category: Dengue virus]] | [[Category: Dengue virus]] | ||
[[Category: Lescar, J.]] | [[Category: Lescar, J.]] | ||
[[Category: Lim, S P.]] | [[Category: Lim, S P.]] | ||
[[Category: Rna dependent rna polymerase]] | [[Category: Rna dependent rna polymerase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 06:47, 13 November 2013
Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region
Template:ABSTRACT PUBMED 24025331
Function
[Q6DLV0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
About this Structure
4c11 is a 2 chain structure with sequence from Dengue virus. Full crystallographic information is available from OCA.
Reference
- Lim SP, Koh JH, Seh CC, Liew CW, Davidson AD, Chua LS, Chandrasekaran R, Cornvik TC, Shi PY, Lescar J. A crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities. J Biol Chem. 2013 Sep 11. PMID:24025331 doi:10.1074/jbc.M113.508606
