4msw: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4msw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4msw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSW OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024128761</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024128761</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Actinomyces lividans krasil'nikov et al. 1965]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Matulef, K.]] | [[Category: Matulef, K.]] | ||
[[Category: Valiyaveetil, F I.]] | [[Category: Valiyaveetil, F I.]] | ||
Revision as of 06:57, 13 November 2013
Y78 ester mutant of KcsA in high K+
Template:ABSTRACT PUBMED 24128761
Function
[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).[1]
About this Structure
4msw is a 3 chain structure with sequence from "actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965 and Lk3 transgenic mice. Full crystallographic information is available from OCA.
Reference
- Matulef K, Komarov AG, Costantino CA, Valiyaveetil FI. Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. Proc Natl Acad Sci U S A. 2013 Oct 15. PMID:24128761 doi:https://dx.doi.org/10.1073/pnas.1314356110
