4c5g: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup)===

~~The entry 4c5g~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME]] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref> [[http://www.uniprot.org/uniprot/PHO_DROME PHO_DROME]] Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:9651589</ref> <ref>PMID:10433918</ref> Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).<ref>PMID:9651589</ref> <ref>PMID:10433918</ref>

~~Authors~~: ~~Alfieri, C~~.~~, Glatt, S~~.~~, Mueller, C~~.W.

==About this Structure==

[[4c5g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5G OCA].

~~Description~~: ~~Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup)~~

==Reference==

[[Category: Alfieri, C.]]

[[Category: Glatt, S.]]

[[Category: Mueller, C W.]]

[[Category: Transcription]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c5g|  PDB=4c5g  |  SCENE=  }}
+===Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup)===
+{{ABSTRACT_PUBMED_24186981}}
-The entry 4c5g is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME]] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref>  [[http://www.uniprot.org/uniprot/PHO_DROME PHO_DROME]] Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:9651589</ref> <ref>PMID:10433918</ref>   Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).<ref>PMID:9651589</ref> <ref>PMID:10433918</ref>
-Authors: Alfieri, C., Glatt, S., Mueller, C.W.
+==About this Structure==
+[[4c5g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5G OCA].
-Description: Crystal structure of the minimal Pho-Sfmbt complex (P6122 spacegroup)
+==Reference==
+<ref group="xtra">PMID:024186981</ref><references group="xtra"/><references/>
+[[Category: Alfieri, C.]]
+[[Category: Glatt, S.]]
+[[Category: Mueller, C W.]]
+[[Category: Transcription]]