4ilw: Difference between revisions
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{{STRUCTURE_4ilw| PDB=4ilw | SCENE= }} | |||
===Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)=== | |||
{{ABSTRACT_PUBMED_24073280}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref> [[http://www.uniprot.org/uniprot/MMP10_HUMAN MMP10_HUMAN]] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. | |||
==About this Structure== | |||
[[4ilw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILW OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024073280</ref><references group="xtra"/><references/> | |||
[[Category: Stromelysin 2]] | |||
[[Category: Batra, J.]] | |||
[[Category: Radisky, E S.]] | |||
[[Category: Soares, A S.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Metalloproteinase]] | |||
[[Category: Metzincin]] | |||
[[Category: Ob-fold]] | |||
[[Category: Protease inhibitor]] | |||
Revision as of 08:19, 13 November 2013
Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)
Template:ABSTRACT PUBMED 24073280
Function
[TIMP2_HUMAN] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.[1] [2] [3] [MMP10_HUMAN] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
About this Structure
4ilw is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Batra J, Soares AS, Mehner C, Radisky ES. Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. PLoS One. 2013 Sep 20;8(9):e75836. doi: 10.1371/journal.pone.0075836. PMID:24073280 doi:https://dx.doi.org/10.1371/journal.pone.0075836
- ↑ Stetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem. 1989 Oct 15;264(29):17374-8. PMID:2793861
- ↑ Goldberg GI, Marmer BL, Grant GA, Eisen AZ, Wilhelm S, He CS. Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8207-11. PMID:2554304
- ↑ Chattopadhyay N, Mitra A, Frei E, Chatterjee A. Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity. J Cancer Res Clin Oncol. 2001 Nov;127(11):653-8. PMID:11710594
