2m5i: Difference between revisions
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{{STRUCTURE_2m5i| PDB=2m5i | SCENE= }} | |||
===NMR structures of human apoptotic protein tBid in LPPG micelle=== | |||
{{ABSTRACT_PUBMED_24158446}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref> | |||
==About this Structure== | |||
[[2m5i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5I OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024158446</ref><references group="xtra"/><references/> | |||
[[Category: Tjandra, N.]] | |||
[[Category: Wang, Y.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Lppg micelle]] | |||
[[Category: Membrane protein]] | |||
[[Category: Tbid]] | |||
Revision as of 08:21, 13 November 2013
NMR structures of human apoptotic protein tBid in LPPG micelle
Template:ABSTRACT PUBMED 24158446
Function
[BID_HUMAN] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.[1]
About this Structure
2m5i is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Wang Y, Tjandra N. Structural insights of tBid, the caspase-8 activated Bid, and its BH3 domain. J Biol Chem. 2013 Oct 24. PMID:24158446 doi:https://dx.doi.org/10.1074/jbc.M113.503680
- ↑ Renshaw SA, Dempsey CE, Barnes FA, Bagstaff SM, Dower SK, Bingle CD, Whyte MK. Three novel Bid proteins generated by alternative splicing of the human Bid gene. J Biol Chem. 2004 Jan 23;279(4):2846-55. Epub 2003 Oct 28. PMID:14583606 doi:https://dx.doi.org/10.1074/jbc.M309769200
