3we2: Difference between revisions
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{{STRUCTURE_3we2| PDB=3we2 | SCENE= }} | |||
===Structure of BLM RQC domain bound to a phosphate ion=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref> | |||
==About this Structure== | |||
[[3we2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WE2 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: DNA helicase]] | |||
[[Category: Kitano, K.]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna helicase]] | |||
[[Category: Winged-helix]] | |||
