4ihf: Difference between revisions
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{{STRUCTURE_4ihf| PDB=4ihf | SCENE= }} | |||
===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI]] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref> [[http://www.uniprot.org/uniprot/G7RM21_ECOC1 G7RM21_ECOC1]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545] | |||
==About this Structure== | |||
[[4ihf]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHF OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Masoudi, A.]] | |||
[[Category: Pemble, C W.]] | |||
[[Category: Raetz, C R.H.]] | |||
[[Category: Acp mediated product release]] | |||
[[Category: Acp recognition domain]] | |||
[[Category: Acyl carrier protein]] | |||
[[Category: Acyltransferase]] | |||
[[Category: Left handed beta helix]] | |||
[[Category: Lipid some]] | |||
[[Category: Lpxd]] | |||
[[Category: Protein-protein complex]] | |||
[[Category: Transferase-lipid binding protein complex]] | |||
Revision as of 08:28, 13 November 2013
Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production
Function
[LPXD_ECOLI] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.[1] [2] [G7RM21_ECOC1] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]
About this Structure
4ihf is a 12 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Helander IM, Lindner B, Seydel U, Vaara M. Defective biosynthesis of the lipid A component of temperature-sensitive firA (omsA) mutant of Escherichia coli. Eur J Biochem. 1993 Mar 1;212(2):363-9. PMID:8444173
- ↑ Bartling CM, Raetz CR. Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis. Biochemistry. 2009 Aug 5. PMID:19655786 doi:10.1021/bi901025v
