4ihh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production===

~~The entry 4ihh~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI]] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref> [[http://www.uniprot.org/uniprot/G7RM21_ECOC1 G7RM21_ECOC1]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]

~~Authors~~: ~~Masoudi, A., Raetz, C.R~~.H.~~, Pemble, C~~.W.

==About this Structure==

[[4ihh]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHH OCA].

~~Description~~: ~~Structural Basis for~~ Acyl-~~substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A~~

==Reference==

[[Category: Masoudi, A.]]

[[Category: Pemble, C W.]]

[[Category: Raetz, C R.H.]]

[[Category: Acp mediated product release]]

[[Category: Acp recognition domain]]

[[Category: Acyl carrier protein]]

[[Category: Acyltransferase]]

[[Category: Left handed beta helix]]

[[Category: Lipid some]]

[[Category: Lpxd]]

[[Category: Protein-protein complex]]

[[Category: Transferase-lipid binding protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ihh|  PDB=4ihh  |  SCENE=  }}
+===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production===
-The entry 4ihh is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI]] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref>  [[http://www.uniprot.org/uniprot/G7RM21_ECOC1 G7RM21_ECOC1]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]
-Authors: Masoudi, A., Raetz, C.R.H., Pemble, C.W.
+==About this Structure==
+[[4ihh]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHH OCA].
-Description: Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Masoudi, A.]]
+[[Category: Pemble, C W.]]
+[[Category: Raetz, C R.H.]]
+[[Category: Acp mediated product release]]
+[[Category: Acp recognition domain]]
+[[Category: Acyl carrier protein]]
+[[Category: Acyltransferase]]
+[[Category: Left handed beta helix]]
+[[Category: Lipid some]]
+[[Category: Lpxd]]
+[[Category: Protein-protein complex]]
+[[Category: Transferase-lipid binding protein complex]]