2fzj: Difference between revisions
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{{STRUCTURE_2fzj| PDB=2fzj | SCENE= }} | {{STRUCTURE_2fzj| PDB=2fzj | SCENE= }} | ||
===New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives=== | ===New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives=== | ||
{{ABSTRACT_PUBMED_17019704}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_MOUSE DYR_MOUSE]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. | |||
==About this Structure== | ==About this Structure== | ||
[[2fzj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2fzj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZJ OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017019704</ref><references group="xtra"/> | <ref group="xtra">PMID:017019704</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Chisum, K.]] | [[Category: Chisum, K.]] | ||
[[Category: Cody, V.]] | [[Category: Cody, V.]] | ||
