4ihg: Difference between revisions
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{{STRUCTURE_4ihg| PDB=4ihg | SCENE= }} | {{STRUCTURE_4ihg| PDB=4ihg | SCENE= }} | ||
===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production=== | ===Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production=== | ||
{{ABSTRACT_PUBMED_24196711}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4ihg]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHG OCA]. | [[4ihg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoc1 Ecoc1] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHG OCA]. | ||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024196711</ref><references group="xtra"/><references/> | ||
[[Category: Ecoc1]] | |||
[[Category: Ecoli]] | |||
[[Category: Masoudi, A.]] | [[Category: Masoudi, A.]] | ||
[[Category: Pemble, C W.]] | [[Category: Pemble, C W.]] | ||
Revision as of 11:37, 20 November 2013
Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production
Template:ABSTRACT PUBMED 24196711
Function
[LPXD_ECOLI] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.[1] [2] [G7RM21_ECOC1] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[HAMAP-Rule:MF_01217][RuleBase:RU003545]
About this Structure
4ihg is a 12 chain structure with sequence from Ecoc1 and Ecoli. Full crystallographic information is available from OCA.
Reference
- Masoudi A, Raetz CR, Zhou P, Pemble Iv CW. Chasing acyl carrier protein through a catalytic cycle of lipid A production. Nature. 2013 Nov 6. doi: 10.1038/nature12679. PMID:24196711 doi:https://dx.doi.org/10.1038/nature12679
- ↑ Helander IM, Lindner B, Seydel U, Vaara M. Defective biosynthesis of the lipid A component of temperature-sensitive firA (omsA) mutant of Escherichia coli. Eur J Biochem. 1993 Mar 1;212(2):363-9. PMID:8444173
- ↑ Bartling CM, Raetz CR. Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis. Biochemistry. 2009 Aug 5. PMID:19655786 doi:10.1021/bi901025v
