2q7o: Difference between revisions

Human purine nucleoside phosphorylase (PNP) was crystallized with, transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H, synthesized with ribosyl mimics of l-stereochemistry. The inhibitors, demonstrate that major driving forces for tight binding of these analogues, are the leaving group interaction and the cationic mimicry of the, transition state, even though large geometric changes occur with, d-Immucillins and l-Immucillins bound to human PNP.

2Q7O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=IMH:'>IMH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Po4 Binding Site For Residue E 290'>AC1</scene> and <scene name='pdbsite=AC2:Imh Binding Site For Residue E 291'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7O OCA].  

[[Category: Almo, S.C.]]

[[Category: Schramm, V.L.]]

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