4fgh: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4fgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4fgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGH OCA]. | ||
==See Also== | |||
*[[Dihydrofolate reductase|Dihydrofolate reductase]] | |||
==Reference== | |||
<ref group="xtra">PMID:022930550</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Barrow, W W.]] | [[Category: Barrow, W W.]] | ||
[[Category: Bourne, C R.]] | [[Category: Bourne, C R.]] | ||
[[Category: Oxidoreductase-inhibitor complex]] | [[Category: Oxidoreductase-inhibitor complex]] | ||
Revision as of 11:46, 20 November 2013
S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor
Template:ABSTRACT PUBMED 22930550
Function
[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
4fgh is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.
See Also
Reference
- Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW. Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Aug 28. doi: 10.1002/cmdc.201200291. PMID:22930550 doi:https://dx.doi.org/10.1002/cmdc.201200291
