3d84: Difference between revisions
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{{STRUCTURE_3d84| PDB=3d84 | SCENE= }} | {{STRUCTURE_3d84| PDB=3d84 | SCENE= }} | ||
===Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine=== | ===Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine=== | ||
{{ABSTRACT_PUBMED_18703847}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_MOUSE DYR_MOUSE]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. | |||
==About this Structure== | ==About this Structure== | ||
[[3d84]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3d84]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D84 OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018703847</ref><references group="xtra"/> | <ref group="xtra">PMID:018703847</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Cody, Vivian]] | [[Category: Cody, Vivian]] | ||
[[Category: Mouse dhfr holo enzyme and ternary ligand complex]] | [[Category: Mouse dhfr holo enzyme and ternary ligand complex]] | ||
