2zv2: Difference between revisions
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===Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609=== | ===Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609=== | ||
{{ABSTRACT_PUBMED_21504895}} | {{ABSTRACT_PUBMED_21504895}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2zv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2zv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZV2 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021504895</ref><references group="xtra"/> | <ref group="xtra">PMID:021504895</ref><references group="xtra"/><references/> | ||
[[Category: Calcium/calmodulin-dependent protein kinase]] | [[Category: Calcium/calmodulin-dependent protein kinase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Kukimoto-niino, M.]] | [[Category: Kukimoto-niino, M.]] | ||
[[Category: Lee, S.]] | [[Category: Lee, S.]] | ||
Revision as of 12:05, 20 November 2013
Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609
Template:ABSTRACT PUBMED 21504895
Function
[KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.[1] [2] [3] [4]
About this Structure
2zv2 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Crystal structure of the CA2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Apr 19. PMID:21504895 doi:10.1074/jbc.M111.251710
- ↑ Hsu LS, Chen GD, Lee LS, Chi CW, Cheng JF, Chen JY. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. J Biol Chem. 2001 Aug 17;276(33):31113-23. Epub 2001 Jun 6. PMID:11395482 doi:https://dx.doi.org/10.1074/jbc.M011720200
- ↑ Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003 Aug 28;550(1-3):57-63. PMID:12935886
- ↑ Hsu LS, Tsou AP, Chi CW, Lee CH, Chen JY. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. J Biomed Sci. 1998;5(2):141-9. PMID:9662074
- ↑ Cao W, Sohail M, Liu G, Koumbadinga GA, Lobo VG, Xie J. Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. RNA Biol. 2011 Nov-Dec;8(6):1061-72. doi: 10.4161/rna.8.6.16691. Epub 2011 Nov 1. PMID:21957496 doi:https://dx.doi.org/10.4161/rna.8.6.16691
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Calcium/calmodulin-dependent protein kinase
- Human
- Kukimoto-niino, M.
- Lee, S.
- Minokoshi, Y.
- RSGI, RIKEN Structural Genomics/Proteomics Initiative.
- Shirouzu, M.
- Suzuki, A.
- Yokoyama, S.
- Yoshikawa, S.
- Ampkk
- Atp-binding
- Beta
- Calcium/calmodulin-dependent protein kinase kinase 2
- Calmodulin-binding
- Camkk2
- E c.2 7.11 17
- Kinase
- Metabolism
- National project on protein structural and functional analyse
- Nppsfa
- Nucleotide-binding
- Phosphoprotein
- Phosphorylation
- Riken structural genomics/proteomics initiative
- Rsgi
- Serine/threonine-protein kinase
- Sto-609
- Structural genomic
- Transferase
- Transferase-transferase inhibitor complex
