3fy8: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3fy8| PDB=3fy8 | SCENE= }} | {{STRUCTURE_3fy8| PDB=3fy8 | SCENE= }} | ||
===Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101=== | ===Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101=== | ||
{{ABSTRACT_PUBMED_19622858}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | ==About this Structure== | ||
[[3fy8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3fy8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FY8 OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019622858</ref><references group="xtra"/> | <ref group="xtra">PMID:019622858</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Dale, G E.]] | [[Category: Dale, G E.]] | ||
[[Category: Oefner, C.]] | [[Category: Oefner, C.]] | ||
Revision as of 12:16, 20 November 2013
Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101
Template:ABSTRACT PUBMED 19622858
Function
[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3fy8 is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.
See Also
Reference
- Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. Epub 2009, Jul 10. PMID:19622858 doi:10.1107/S0907444909013936
