3dat: Difference between revisions
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{{STRUCTURE_3dat| PDB=3dat | SCENE= }} | {{STRUCTURE_3dat| PDB=3dat | SCENE= }} | ||
===Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase=== | ===Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase=== | ||
{{ABSTRACT_PUBMED_19374017}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |||
==About this Structure== | ==About this Structure== | ||
[[3dat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3dat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_sterne) Bacillus anthracis (strain sterne)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAT OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019374017</ref><references group="xtra"/> | <ref group="xtra">PMID:019374017</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Bennett, B C.]] | [[Category: Bennett, B C.]] | ||
Revision as of 12:21, 20 November 2013
Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase
Template:ABSTRACT PUBMED 19374017
Function
[Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
About this Structure
3dat is a 1 chain structure with sequence from Bacillus anthracis (strain sterne). Full crystallographic information is available from OCA.
See Also
Reference
- Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. PMID:19374017
