4lxa: Difference between revisions
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{{STRUCTURE_4lxa| PDB=4lxa | SCENE= }} | {{STRUCTURE_4lxa| PDB=4lxa | SCENE= }} | ||
===Crystal Structure of Human Beta Secretase in Complex with Compound 11a=== | ===Crystal Structure of Human Beta Secretase in Complex with Compound 11a=== | ||
{{ | {{ABSTRACT_PUBMED_23981898}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
[[4lxa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4lxa]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXA OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:023981898</ref><references group="xtra"/><references/> | ||
[[Category: Human]] | |||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Bourgier, E.]] | [[Category: Bourgier, E.]] | ||
[[Category: Rondeau, J M.]] | [[Category: Rondeau, J M.]] | ||
Revision as of 12:25, 20 November 2013
Crystal Structure of Human Beta Secretase in Complex with Compound 11a
Template:ABSTRACT PUBMED 23981898
Function
[BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.[1] [2]
About this Structure
4lxa is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Jacobson LH, Staufenbiel M, Desrayaud S, Rondeau JM, Mobitz H, Neumann U. Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5300-6. doi: 10.1016/j.bmcl.2013.07.071. , Epub 2013 Aug 9. PMID:23981898 doi:https://dx.doi.org/10.1016/j.bmcl.2013.07.071
- ↑ Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. PMID:10677483
- ↑ Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010 Aug;24(8):2783-94. doi: 10.1096/fj.09-146357. Epub 2010 Mar 30. PMID:20354142 doi:10.1096/fj.09-146357
