2qad: Difference between revisions

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==Overview==

The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and, facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on, gp120. We applied nuclear magnetic resonance and crystallographic, techniques to analyze the structure of the CCR5 N terminus and that of the, tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The, conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d, (extended loop) are surprisingly different. Nonetheless, a critical, sulfotyrosine on CCR5 and on 412d induces similar structural, rearrangements in gp120. These results now provide a framework for, understanding HIV-1 interactions with the CCR5 N terminus during viral, entry and define a conserved site on gp120, whose recognition of, sulfotyrosine engenders posttranslational mimicry by the immune system.

The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system.

==Disease==

Known diseases associated with this structure: CD4 lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]]

==About this Structure==

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[[Category: Human immunodeficiency virus 1]]

[[Category: Protein complex]]

[[Category: Huang, C.C.]]

[[Category: Huang, C C.]]

[[Category: Kwong, P.D.]]

[[Category: Kwong, P D.]]

[[Category: Robinson, J.]]

[[Category: Tang, M.]]

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[[Category: viral protein/immune system]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and, facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on, gp120. We applied nuclear magnetic resonance and crystallographic, techniques to analyze the structure of the CCR5 N terminus and that of the, tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The, conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d, (extended loop) are surprisingly different. Nonetheless, a critical, sulfotyrosine on CCR5 and on 412d induces similar structural, rearrangements in gp120. These results now provide a framework for, understanding HIV-1 interactions with the CCR5 N terminus during viral, entry and define a conserved site on gp120, whose recognition of, sulfotyrosine engenders posttranslational mimicry by the immune system.
+The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d (extended loop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for understanding HIV-1 interactions with the CCR5 N terminus during viral entry and define a conserved site on gp120, whose recognition of sulfotyrosine engenders posttranslational mimicry by the immune system.
+==Disease==
+Known diseases associated with this structure: CD4  lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]]
 ==About this Structure==
@@ Line 14: / Line 17: @@
 [[Category: Human immunodeficiency virus 1]]
 [[Category: Protein complex]]
-[[Category: Huang, C.C.]]
+[[Category: Huang, C C.]]
-[[Category: Kwong, P.D.]]
+[[Category: Kwong, P D.]]
 [[Category: Robinson, J.]]
 [[Category: Tang, M.]]
@@ Line 24: / Line 27: @@
 [[Category: viral protein/immune system]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:58:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:37:42 2008''