4c7o: Difference between revisions

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~~'''Unreleased structure'''~~

===The structural basis of FtsY recruitment and GTPase activation by SRP RNA===

The ~~entry 4c7o~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/SRP54_ECOLI SRP54_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:2171778</ref> <ref>PMID:1279430</ref> <ref>PMID:1331806</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15140892</ref> [[http://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>

~~Authors~~: ~~Voigts-Hoffmann, F~~.~~, Schmitz, N~~.~~, Shen, K~~.~~, Shan, S~~.O.~~, Ataide, S~~.F.~~, Ban, N~~.

==About this Structure==

[[4c7o]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7O OCA].

~~Description~~: ~~The structural basis of FtsY recruitment and GTPase activation by SRP RNA~~

==Reference==

[[Category: Escherichia coli]]

[[Category: Ataide, S F.]]

[[Category: Ban, N.]]

[[Category: Schmitz, N.]]

[[Category: Shan, S O.]]

[[Category: Shen, K.]]

[[Category: Voigts-Hoffmann, F.]]

[[Category: Gdp alf3/4]]

[[Category: Nuclear protein]]

[[Category: Nuclear protein-rna complex]]

[[Category: Protein translocation]]

[[Category: Signal recognition particle]]

[[Category: Signal recognition particle receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c7o|  PDB=4c7o  |  SCENE=  }}
+===The structural basis of FtsY recruitment and GTPase activation by SRP RNA===
+{{ABSTRACT_PUBMED_24211265}}
-The entry 4c7o is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SRP54_ECOLI SRP54_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:2171778</ref> <ref>PMID:1279430</ref> <ref>PMID:1331806</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15140892</ref>  [[http://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>
-Authors: Voigts-Hoffmann, F., Schmitz, N., Shen, K., Shan, S.O., Ataide, S.F., Ban, N.
+==About this Structure==
+[[4c7o]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7O OCA].
-Description: The structural basis of FtsY recruitment and GTPase activation by SRP RNA
+==Reference==
+<ref group="xtra">PMID:024211265</ref><references group="xtra"/><references/>
+[[Category: Escherichia coli]]
+[[Category: Ataide, S F.]]
+[[Category: Ban, N.]]
+[[Category: Schmitz, N.]]
+[[Category: Shan, S O.]]
+[[Category: Shen, K.]]
+[[Category: Voigts-Hoffmann, F.]]
+[[Category: Gdp alf3/4]]
+[[Category: Nuclear protein]]
+[[Category: Nuclear protein-rna complex]]
+[[Category: Protein translocation]]
+[[Category: Signal recognition particle]]
+[[Category: Signal recognition particle receptor]]